So it just crashes before you can even do anything? Or is there a button you click that's crashing it.
Also do you have any stamps or saves? (located in the stamps/ and Saves/ folders). Try deleting or temporarily renaming the folders to see if this fixes it. Also if that doesn't work, try deleting powder.pref. If that doesn't work, redownload the game and extract the exe into an empty folder with nothing else in it, and chances are it won't crash. If it still does ... i'm just not sure.
Also what type of crash is it? Do you get that new bluescreen thing we added in game? Or does windows say "this program is not responding", or does it just suddenly close?