Hosted and produced by Lazlow (who also co-wrote the script along with Dan Houser), Chatterbox FM is the only radio station in the game that does not feature music. Much like the talk radio stations in the real world, Chatterbox features a format in which listeners call in with opinions, concerns, and complaints, and the host responds with his take on the situation.
The station features two long interviews with fictional Liberty City characters. The first is with Fernando Martinez—a recurring character in the GTA series—who is the founder of Fernando's New Beginnings, which is billed as a sort of revolutionary new "miracle" therapy designed to save struggling marriages. Martinez speaks in a heavily exaggerated "Euro-accent"; when pressed about his heritage, he replies that he is "Latin." Martinez spends the length of the interview deflecting any deep review of his services, and instead relays his particular brand of folksy and absurdist wisdom. At the end of his interview, however, it is revealed that his therapeutic "techniques" are merely a thinly-veiled excuse for the husband to commit adultery when it suits him. Martinez asserts that whenever a man is tired of his wife, he should cheat on her, thereby reducing the anxiety he feels towards his wife, and thus "saving" the marriage. Until the next time. This results in Lazlow throwing Fernando out the studio, accusing him of being "just a cheap pimp from upstate". The second interview is with the pacifist, organic food-eating martial artist Reed Tucker, whom Lazlow constantly makes fun of. Towards the end of the interview, tired of being mocked, Reed attempts to karate chop the studio's desk "into two half desks," claiming he "already visioned" it. After failing miserably, Lazlow starts mocking him by adopting his voice and making comments about him ("I bruise easily, don't throw any tofu or bean curds at me"). It is said by both Lazlow and Reed that he has a food market called "Now and Zen" in Trenton, but this does not exist in the game.